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Tenofovir Disoproxil Fumarate CAS 202138-50-9 For Treat AIDS Pharma Raw Materials

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Tenofovir Disoproxil Fumarate CAS 202138-50-9 For Treat AIDS Pharma Raw Materials

Brand Name : FuLu
Model Number : 202138-50-9
Certification : ISO9001
Place of Origin : China
MOQ : Negotiable
Price : Negotiable
Payment Terms : Western Union, MoneyGram, T/T, Bit-coin
Supply Ability : Mass stock
Delivery Time : Within 24h after payment
Packaging Details : 1kg Sterile aluminum foil bag or discreet and tight safe packing for Customs pass guaranteed
Product name : Tenofovir disoproxil fumarate
Molecular Formula : C23H34N5O14P
Molecular Weight : 635.51
Function : Treat AIDS
Appearance : A White to off white crystalline power
CAS : 202138-50-9
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Tenofovir Disoproxil Fumarate CAS 202138-50-9 For Treat AIDS Pharma Raw Materials

Quack detail


Product name:Tenofovir disoproxil fumarate
Other NameTenofovir disoproxil fumarate;TENOFOVIR DISOPROXIC;9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate;2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-;Aids031697;Aids-031697;Bis(neopentyloc)pmpa;Tenofovir diisoproxil fuMarate
OriginalChina
CAS202138-50-9
Molecular formulaC23H34N5O14P
Molecular Weight635.51
Brand nameFulu
Delivery timewithin 24 hours upon receipt of payment
DeliveryFast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity99%
PackageDiscreet and Hidden package according to specific requirement
AppearanceWhite Crystalline Powder
CertificationSGS, ISO 9001, KOSHER
Payment TermsWestern Union, Money Gram , T/T, Bitcoin
Minimum Order Quantity10 g
PriceNegotiable

Technical Test Sheet


Product nameTenofovir Disoproxil FumarateCAS no.202138-50-9
ItemsSpecificationsResults
AppearanceA White to off white crystalline powderWhite crystalline powder
SolubilityFreely soluble in DMF and in methanol,sparingly soluble in waterConform
IdentificationA).By IR: PositiveConform
B).By HPLC: PositiveConform
Residue on ignition0.2% maxcomplies
Water(By K.F)1.0% max0.4%
Heavy metals20ppm maxConform
Related Substance
(by HPLC)
a(Tenofovir): 0.15% maxNot detected
b(Adenine): 0.15% maxNot detected
c(Tenofovir isoproxil monoester): 1.0% max0.29%
d(Tenofovir Disoproxil ethyl ester):0.15 maxNot detected
e(Tenofovir isopropyl isoproxil ): 0.3% maxNot detected
f(Tenofovir Disoproxil carbamate):0.15% maxNot detected
g(Tenofovir Disoproxil Dimer):0.15%Not detected
Any Individual unspecified impuriy:0.1%0.09%
Total impurity: 2.0% max0.40%
Enantiomeric Purity1.0% maxNot detected
Tenofovir Disoproxil Related compound B5PPM maxNot detected
Fumaric Acid17.5~19.0%18.03%
Residual solventsEthanol: 5000ug/g max1159ug/g
Isopropyl alcohol: 5000ug/g max1077ug/g
Methylene chloride: 600ug/g maxNot detected
NMP: 530ug/g maxNot detected
Assay (on anhydrous basis)98.0% to 102.0%99.25%
ConclusionComply with USP34

Descriptions


Tenofovir is used in combination with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immunodeficiency syndrome (AIDS).


Pharmacokinetics


Tenofovir is hardly absorbed through the gastrointestinal tract, for this reason, prodrug of Tenofovir has been developed by esterification, and then to make tenofovir fumarate ester. Tenofovir ester is water-soluble, can be rapidly absorbed and degraded into the active tenofovir, and then was metabolized to the active Tenofovir disoproxil.


Tenofovir will reach the peak of plasma Concentration within 1-2 h after administration. When combined with food service, the bioavailability of Tenofovir can be increased by 40%. Intracellular half-life of Tenofovir disoproxil is about 10 h, it needs dosing everyday. Because Tenofovir is not a CYP-450 substrate, this may decrease the possibility of interactions with other drugs caused by CYP450. Elimination of Tenofovir is by glomerular filtration and active tubular secretion. Approximately 70% to 80% is recovered in urine as unchanged drug. Elimination half-life is approximately 17 h.


Indications: Tenofovir is indicated for the treatment of HIV, HBV infection. This product also can cooperated with other reverse transcriptase inhibitors for HIV-1 infection and hepatitis B treatment.


Our Advantages


Best QualityProfessional leading manufacturers in China.Strict quality control before products are allowed to sell.
Competitive PriceFactory direct sales. Best prices you're sure to be satisfied.
Safe PackingProfessional packing department which have more than 16 years experience in disguising packages
Fast DeliveryPlenty in stock,delivery within 24 hours after the payment.Fast and secure delivery by DHL, TNT, FedEx, HKEMS, UPS, etc.
PaymentT/T, Western Union, Money Gram, Bitcoin.
ServicePhotos of parcel and tracking number offered timely; 24/7 online helpful service
DiscountSpecials are possible when client's order is big enough, including the discount policy


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